Blar i forfatter "Cioni, Lara"

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    • Fluorine Mass Balance, including Total Fluorine, Extractable Organic Fluorine, Oxidizable Precursors, and Target Per- and Polyfluoroalkyl Substances, in Pooled Human Serum from the Tromsø Population in 1986, 2007, and 2015 

      Cioni, Lara; Plassmann, Merle; Benskin, Jonathan P.; Coelho, Ana Carolina; Nøst, Therese Haugdahl; Rylander, Karin Charlotta Maria; Nikiforov, Vladimir; Sandanger, Torkjel Manning (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-25)
      Of the thousands of per- and polyfluoroalkyl substances (PFAS) known to exist, only a small fraction (≤1%) are commonly monitored in humans. This discrepancy has led to concerns that human exposure may be underestimated. Here, we address this problem by applying a comprehensive fluorine mass balance (FMB) approach, including total fluorine (TF), extractable organic fluorine (EOF), total oxidizable ...

    • Human Exposure to PFAS and Other Anthropogenic Organofluorine Chemicals in Tromsø between 1986 and 2015 

      Cioni, Lara (Doctoral thesis; Doktorgradsavhandling, 2023-12-06)
      Summary In the last century, there has been a dramatic increase in chemical production and number and diversity of chemicals produced. Especially, organofluorine chemistry has increased its importance due to applications in pharmaceuticals, agrochemicals, refrigerant gases and in consumer products and industry with fluoropolymers and per- and polyfluoroalkyl substances (PFAS). PFAS are receiving ...

    • Legacy perfluoroalkyl acids and their oxidizable precursors in plasma samples of Norwegian women 

      Miranda Fernandes Coelho, Ana Carolina; Cioni, Lara; Van Dreunen, Wendy; Berg, Vivian; Rylander, Karin Charlotta Maria; Urbarova, Ilona Halva; Herzke, Dorte; Sandanger, Torkjel M (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-12)
      Humans are exposed to perfluoroalkyl acids (PFAA) mainly through direct pathways, such as diet and drinking water, but indirect exposure also occurs when PFAA precursors break down to form legacy PFAA. Exposure to PFAA precursors raises particular concern, as neither the exposure nor the precursors themselves have been well described. In the present study, we aimed to assess the indirect contribution ...

    • Optimization of a low flow sampler for improved assessment of gas and particle bound exposure to chlorinated paraffins 

      Al Saify, Insam; Cioni, Lara; van Mourik, Louise M.; Brandsma, Sicco H.; Warner, Nicholas Alexander (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-23)
      An optimized low volume sampler was developed to determine both gas- and particle bound concentrations of short and medium-chain chlorinated paraffins (S/MCCPs). Background contamination was limited by the sampler design, providing method quantification limits (MQLs) at least two orders of magnitude lower than other studies within the gas (MQL: 500 pg (ΣSCCPs), 1.86 ng (ΣMCCPs)) and particle (MQL: ...

    • Total Oxidizable Precursors Assay for PFAS in Human Serum 

      Cioni, Lara; Nikiforov, Vladimir; Miranda Fernandes Coelho, Ana Carolina; Sandanger, Torkjel M; Herzke, Dorte (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-23)
      Per- and polyfluoroalkyl substances (PFAS) are a class of chemicals including over 4700 substances. As a limited number of PFAS is routinely analyzed in human serum, complementary analytical methods are required to characterize the overlooked fraction. A promising tool is the total oxidizable precursors (TOP) assay to look for precursors by oxidation to perfluoroalkyl acids (PFAA). The TOP assay was ...